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| | 4-Chloro-3-Methyl-3H-iMidazo[4,5-c]pyridine Basic information |
| | 4-Chloro-3-Methyl-3H-iMidazo[4,5-c]pyridine Chemical Properties |
| Boiling point | 331.8±45.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.42±0.30(Predicted) | | Appearance | White to off-white Solid |
| | 4-Chloro-3-Methyl-3H-iMidazo[4,5-c]pyridine Usage And Synthesis |
| Synthesis | NaH (78 mg, 1.95 mmol, 60% oil dispersion) was added to a solution of 4-chloroimidazo[4,5-C]pyridine (100 mg, 0.65 mmol) in DMF (3 mL) at 0 °C. The mixture was stirred at 0 °C for 40 min under nitrogen protection. Subsequently, iodomethane (277 mg, 1.95 mmol) was added at 0 °C. The reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous NH4Cl and extracted with EtOAc (20 mL x 3). The organic layers were combined, dried with magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by preparative HPLC to afford 4-chloro-1-methyl-1H-imidazo[4,5-c]pyridine (40.3 mg, yellow oil) and 4-chloro-3-methyl-3H-imidazo[4,5-c]pyridine (41.0 mg, yellow oil).LRMS (m/z): [M + H]+ Calculated Values 168.2, 170.2; measured values 168.0, 170.2. | | References | [1] Patent: WO2016/101119, 2016, A1. Location in patent: Page/Page column 99; 100 |
| | 4-Chloro-3-Methyl-3H-iMidazo[4,5-c]pyridine Preparation Products And Raw materials |
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