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| | Isavuconazonium sulfate Basic information |
| Product Name: | Isavuconazonium sulfate | | Synonyms: | BAL 8557-002;N-Methylglycine [2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester sulfate (1:1);API-Antifungal Infection;ISAVUCONAZOLE SULFATE;Isavuconazonium sulfate (BAL8557);Isavuconazonium sulfate,inhibit,antifungal,prodrug,aspergillosis,BAL8557-002,Fungal,mucormycosis,invasive,Isavuconazonium,Inhibitor,infections;Isavuconazole Impurity 40 Sulphite;1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium hydrogen sulfate | | CAS: | 946075-13-4 | | MF: | C35H36F2N8O9S2 | | MW: | 814.84 | | EINECS: | | | Product Categories: | API | | Mol File: | 946075-13-4.mol |  |
| | Isavuconazonium sulfate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:93.34(Max Conc. mg/mL);114.55(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);12.27(Max Conc. mM) | | form | A crystalline solid | | color | White to off-white | | InChIKey | LWXUIUUOMSMZKJ-XHOYWDQFNA-M | | SMILES | S(O)([O-])(=O)=O.[C@@](C1C=C(F)C=CC=1F)(O)(CN1N=C[N+](C(C)OC(=O)N(C2N=CC=CC=2COC(=O)CNC)C)=C1)[C@H](C1SC=C(C2C=CC(C#N)=CC=2)N=1)C |&1:5,41,r| |
| WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Repr. 2
STOT RE 1 |
| | Isavuconazonium sulfate Usage And Synthesis |
| Description | Isavuconazonium sulfate is an orally bioavailable, safe, second-generation triazole antifungal agent approved by the U.S. Food and Drug Administration (FDA) for the treatment of invasive Aspergillosis and invasive Mucormycosis in adults 18 years of age and older. Currently available under the brand name Cresemba, the most common side effects include liver test abnormalities, nausea, vomiting, dyspnea, abdominal pain, diarrhoea, injection site reactions, headache, hypokalemia and rash. | | Uses | Isavuconazonium Sulfate can be prepared to be used as an antifungal drug. | | Definition | ChEBI: An azaheterocycle sulfate salt that is a prodrug for isavuconazole, an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis. | | in vivo | Isavuconazonium sulfate (215 mg/kg; p.o.; Three times a day for 4 days) has anti-R.delemar virus activity in ICR mice infected with mucormycosis[4].
| Animal Model: | Neutropenic male ICR mouse model of intratracheal infection[4] | | Dosage: | 215 mg/kg | | Administration: | Oral gavage (p.o.); Three times a day for 4 days. | | Result: | Increased the survival rate of neutropenic mice infected with R. delemar.
Reduced fungal load in the lungs and brains of mice.
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| | Metabolism | Isavuconazonium sulfate (Cresemba) is the water-soluble prodrug of isavuconazole, a broad-spectrum antifungal triazoles with activity against yeasts, molds, and dimorphic fungi and available as intravenous solution and as capsules for oral administration. Isavuconazonium sulfate is metabolized mainly by serum butylcholinesterase to isavuconazole. Isavuconazole is metabolized to inactive metabolites in the liver via CYP3A4 and CYP3A5 isoenzymes and uridine diphosphate-glucuronosyl transferase[1]. | | References | [1] Kumar, Sunil et al. “11. Thiazole: A privileged scaffold in drug discovery.” 2016. 0. |
| | Isavuconazonium sulfate Preparation Products And Raw materials |
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