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Antipain hydrochloride dihydrate

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Antipain hydrochloride dihydrate Basic information
Product Name:Antipain hydrochloride dihydrate
Synonyms:N2-[[(1-Carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide;PHE-ARG-VAL-ARG-CHO;Antipain research grade;4-((aminoiminomethyl)amino)-1-formylbutyl)-;N2-[[(1-carboxyphenethyl)amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide;ANTIPAIN ~10000 U/MG;Nα-[N2-[[(1-Carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl]-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide;Nα-[Nα-[[(1-Carboxy-2-phenylethyl)amino]carbonyl]-L-arginyl]-N-(1-formyl-4-guanidinobutyl)-L-valinamide
CAS:37691-11-5
MF:C27H44N10O6
MW:604.7
EINECS:253-631-0
Product Categories:A - K;Aldehydes;Antibacterial;Antibiotics A to Z;Antibiotics;Antibiotics A-F;Antibiotics by Application;Antineoplastic and Immunosuppressive Antibiotics;Building Blocks;C13-C60;Carbonyl Compounds;Chemical Structure Class;Chemical Synthesis;Inhibits an Enzyme;Mechanism of Action;Organic Building Blocks;Peptides;Spectrum of Activity;Pepetides
Mol File:37691-11-5.mol
Antipain hydrochloride dihydrate Structure
Antipain hydrochloride dihydrate Chemical Properties
density 1.38
storage temp. −20°C
pka3.84±0.10(Predicted)
Specific Activity>50000U/mg
BRN 6837629
InChIKeySDNYTAYICBFYFH-KTYMLHDXSA-N
SMILES[H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C
Safety Information
WGK Germany 3
RTECS YV9350700
F 1-10
Storage Class11 - Combustible Solids
MSDS Information
Antipain hydrochloride dihydrate Usage And Synthesis
UsesAntipain is a reversible inhibitor of Ser and Cys proteases.
General DescriptionChemical structure: peptide
Biochem/physiol ActionsReversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
in vivo

The intact, cycling female mice received subcutaneous injections of Antipain (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].

Antipain hydrochloride dihydrate Preparation Products And Raw materials
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