| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
|
| | 4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide Basic information |
| | 4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:5): 300 μg/ml; DMSO: 14 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid |
| | 4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide Usage And Synthesis |
| Description | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA. However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC. | | Uses | A histone deacetylase (HDAC1) inhibitor | | References | [1] STACY W. REMISZEWSKI. Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates[J]. Journal of Medicinal Chemistry, 2002, 45 4: 753-757. DOI: 10.1021/jm015568c
[2] SYBILLE WITTICH. Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines.[J]. Anti-Cancer Drugs, 2005, 16 6: 635-643. DOI: 10.1097/00001813-200507000-00008
[3] NANIKA COETZEE. Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites.[J]. ACS Applied Electronic Materials, 2020: 2355. DOI: 10.1038/s41598-020-59298-4 |
| | 4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide Preparation Products And Raw materials |
|