| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:Ferutinin
CAS:41743-44-6
Purity:>=98% Package:10mg/RMB 3699.90;1mg/RMB 599.90;5mg/RMB 2199.90
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| Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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| Tel: |
021-51320588 |
| Email: |
tauto@tautobiotech.com |
| Products Intro: |
Product Name:Ferutinin (high purity)
CAS:41743-44-6
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:AG-CN2-0007-M010
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| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:FERUTININ
CAS:41743-44-6
Purity:>=98% Package:10mg Remarks:S55003
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| | FERUTININ Basic information |
| Product Name: | FERUTININ | | Synonyms: | FERUTININ;TEFESTROL;Ferutinin (high purity);Ferutinol p-hydroxybenzoate;Jaeschkeanadiol p-hydroxybenzoate;Ferutinin >=98% (HPLC);Benzoic acid, 4-hydroxy-, (3R,3aS,4S,8aR)-1,2,3,3a,4,5,8,8a-octahydro-3-hydroxy-6,8a-dimethyl-3-(1-methylethyl)-4-azulenyl ester;Ferutinin, ERalpha agonist | | CAS: | 41743-44-6 | | MF: | C22H30O4 | | MW: | 358.47 | | EINECS: | | | Product Categories: | | | Mol File: | 41743-44-6.mol |  |
| | FERUTININ Chemical Properties |
| Boiling point | 489.0±45.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: Soluble | | form | White to off-white solid | | pka | 8.12±0.15(Predicted) | | color | White to off-white | | InChI | 1S/C22H30O4/c1-14(2)22(25)12-11-21(4)10-9-15(3)13-18(19(21)22)26-20(24)16-5-7-17(23)8-6-16/h5-9,14,18-19,23,25H,10-13H2,1-4H3/t18-,19+,21-,22+/m0/s1 | | InChIKey | CYSHNJQMYORNJI-YUVXSKOASA-N | | SMILES | CC1=CC[C@](CC[C@@]2(O)C(C)C)(C)[C@@]2([H])[C@@H](OC(C3=CC=C(O)C=C3)=O)C1 | | LogP | 5.720 (est) |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Chronic 4 |
| | FERUTININ Usage And Synthesis |
| Uses | Ferutinin acts as an agonist for estrogen receptor (ER) α. It also increases calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes. | | Biological Activity | Ferutinin can suppress tumor development without causing systemic toxicity in various tumor cells and animal cancer models. It possesses estrogenic properties and a protective role against uterine carcinoma. Ferutinin exhibits anti-cancer action in estrogen-dependent breast cancer cells.', 'Ferutinin is a strong agonist for estrogen receptor (ER)α and agonist/antagonist for Erβ with IC50 values of 33.1 nM for ERα and 180.5 nM for Erβ. It has been shown to have both ionophoretic and apoptotic properties. It increases calcium permeability in the lipid bilayer and has been shown to improve bone regeneration in a r at study. It caused significant regression in tumor size in a mouse colon cancer model. | | IC 50 | ERα: 33.1 nM (IC50); ERβ: 180.5 nM (IC50) |
| | FERUTININ Preparation Products And Raw materials |
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