142479-62-7
| 中文名称 | 142479-62-7 |
|---|---|
| 中文同义词 | 化合物GLUTEN EXORPHIN C;谷蛋白外啡肽C;五肽Gluten Exorphin C;谷朊粉阿片肽Gluten Exorphin C |
| 英文名称 | DELTA-OPIOID RECEPTOR PEPTIDE TRIFLUOROACETATE SALT |
| 英文同义词 | TYR-PRO-ILE-SER-LEU TRIFLUOROACETATE SALT;exorphin c;EXORPHIN C TRIFLUOROACETATE SALT;DELTA-OPIOID RECEPTOR PEPTIDE TRIFLUOROACETATE SALT;exorphin C trifluoroacetate;L-Leucine, L-tyrosyl-L-prolyl-L-isoleucyl-L-seryl-;H-YPISL-OH;inhibit,Gluten Exorphin C,Inhibitor,Opioid Receptor |
| CAS号 | 142479-62-7 |
| 分子式 | C29H45N5O8 |
| 分子量 | 591.7 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 142479-62-7.mol |
| 结构式 |  |
142479-62-7 性质
| 沸点 | 969.3±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.264±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.30±0.10(Predicted) |
| 颜色 | 白色至米白色 |
| 序列 | Tyr-Pro-Ile-Ser-Leu |
IC50: 40 μM (μ opioid), 13.5 μM (δ opioid)
Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC 50 s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity.
安全信息
| WGK Germany | 3 |
|---|
| 提供商 | 语言 |
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英文
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