Crebinostat manufacturers
- Crebinostat
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- $47.00
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2026-08-08
- CAS:1092061-61-4
- Purity: 99.49%
- Supply Ability: 10g
- Crebinostat
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- $1.00
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2025-09-01
- CAS:1092061-61-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20T
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| | Crebinostat Basic information |
| Product Name: | Crebinostat | | Synonyms: | CREBINOSTAT;CRBT crebinostat;CRBT,CREBINOSTAT;Heptanoic acid, 7-(hydroxyamino)-7-oxo-, 2-([1,1'-biphenyl]-4-ylmethylene)hydrazide;7-(2-([1,1'-Biphenyl]-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide;7-(2-([1,1'-Biphenyl]-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide , Crebinostat;7-(2-([1,1'-Biphenyl]-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide | | CAS: | 1092061-61-4 | | MF: | C20H23N3O3 | | MW: | 353.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1092061-61-4.mol |  |
| | Crebinostat Chemical Properties |
| density | 1.16±0.1 g/cm3(Predicted) | | pka | 9.47±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | Crebinostat Usage And Synthesis |
| Uses | Crebinostat is a small molecular inhibitor of histone deacetylases (HDACs). it also modulates chromatin-mediated neuroplasticity. | | Definition | ChEBI: N'-hydroxy-N-[(4-phenylphenyl)methylideneamino]heptanediamide is a member of biphenyls. | | in vivo | Crebinostat (25 mg/kg; IP; for 10 days) enhances memory of contextual fear conditioning in mice; induces an increase in total hippocampal acetylation of H4K12 and H3K9[1]. | Animal Model: | Male C57BL/6J mice (9-10 weeks)[1] | | Dosage: | 25 mg/kg | | Administration: | IP; alternate daily between left and right sides of the abdomen, for 10 days | | Result: | Enhanced memory of contextual fear conditioning in mice; induced a trend towards an increase in total hippocampal acetylation of both H4K12 and H3K9. |
| | IC 50 | HDAC1: 0.7 nM (IC50); HDAC2: 1.0 nM (IC50); HDAC3: 2.0 nM (IC50); HDAC6: 9.3 nM (IC50) |
| | Crebinostat Preparation Products And Raw materials |
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