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| | Azido-PEG3-SS-PEG3-azide Basic information |
| | Azido-PEG3-SS-PEG3-azide Chemical Properties |
| solubility | Soluble in DMSO | | form | Liquid | | color | Light yellow to brown |
| | Azido-PEG3-SS-PEG3-azide Usage And Synthesis |
| Description | Azido-PEG3-SS-PEG3-azide is a PEG linker containing two terminal azide moieties and a cleavable disulfide bond. The azide groups can undergo copper-catalyzed Click Chemistry reactions with reagents such as alkynes, DBCO and BCN. The disulfide bond can be cleaved via reduction reactions using a Dithiothreitol (DTT) reagent. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media. | | Uses | Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-SS-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG3-SS-PEG3-azide Preparation Products And Raw materials |
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