|
|
| | Azido-PEG6-PFP ester Basic information |
| Product Name: | Azido-PEG6-PFP ester | | Synonyms: | Azido-PEG6-PFP ester;(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate;N3-PEG6-CH2CH2COOPFP;Perfluorophenyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate | | CAS: | 1818294-47-1 | | MF: | C21H28F5N3O8 | | MW: | 545.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1818294-47-1.mol |  |
| | Azido-PEG6-PFP ester Chemical Properties |
| solubility | Soluble in DCM |
| | Azido-PEG6-PFP ester Usage And Synthesis |
| Description | Azido-PEG6-PFP ester is a a high purity PEG linker containing azide and PFP ester moities. The azide can participate in Click Chemistry reactions with alkynes, such as DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester. | | Uses | Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG6-PFP ester Preparation Products And Raw materials |
|