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| | 1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid Basic information |
| Product Name: | 1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid | | Synonyms: | Tetrahydroquinoline-6-carboxylic acid;6-Carboxy-1,2,3,4-tetrahydroquinoline;1,2,3,4-Tetrahydroquinoline-6-carboxylic acid;1,2,3,4-Tetrahydroquinoline-6-carboxylic acid 95+%;6-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-;1,2,3,4-Tetrahydro-6-quinolinecarboxylic;1,2,3,4-Tetrahydro-6-quinolinecarboxylicAci;1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid | | CAS: | 5382-49-0 | | MF: | C10H11NO2 | | MW: | 177.2 | | EINECS: | | | Product Categories: | | | Mol File: | 5382-49-0.mol |  |
| | 1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid Chemical Properties |
| Melting point | 168 °C | | Boiling point | 382.6±31.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 4.96±0.20(Predicted) | | Appearance | Off-white to yellow Solid |
| Hazard Codes | Xi,T | | Risk Statements | 25 | | Safety Statements | 45 | | Hazard Note | Irritant | | HS Code | 2933499090 |
| | 1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid Usage And Synthesis |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 39, p. 2044, 1974 DOI: 10.1021/jo00928a014 | | Synthesis | GENERAL STEPS: 1-Acetyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile (50 mmol) was dissolved in 8 M hydrochloric acid (150 mL) and the reaction was carried out at reflux for 18 hours. Upon completion of the reaction, the mixture was cooled and the pH was adjusted with sodium hydroxide solution to about 3. The precipitated 1,2,3,4-tetrahydroquinoline-6-carboxylic acid was separated by filtration, washed with water and dried. Yield: 61%.1H NMR (D6-DMSO) δ: 1.79 (m, 2H), 2.68 (m, 2H), 3.23 (m, 2H), 5.45 (br, 1H), 6.48 (d, 1H), 7.45-7.50 (m, 2H). | | References | [1] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 31-32 |
| | 1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid Preparation Products And Raw materials |
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