|
|
| | ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride Basic information |
| Product Name: | ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride | | Synonyms: | ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride;(5-(Methylsulfonyl)pyridin-2-yl)methanamine hydrochloride;([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride(WX603194);([5-(METHYLSULFONYL)PYRIDIN-2-YL]METHYL)AMINE HCL;2-Pyridinemethanamine, 5-(methylsulfonyl)-, monohydrochloride;1-[5-(methane sulfonyl)pyridin-2-yl]methanamine Hydrochloride;[5-(methanesulfonyl)pyridin-2-yl]methanaminium chloride | | CAS: | 848141-14-0 | | MF: | C7H11ClN2O2S | | MW: | 222.69244 | | EINECS: | | | Product Categories: | | | Mol File: | 848141-14-0.mol | ![([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride Structure](CAS/20180703/GIF/848141-14-0.gif) |
| | ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | White to off-white Solid |
| | ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of (5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride from 5-(methylsulfonyl)pyridine-2-carbonitrile was as follows: 5-(methylsulfonyl)pyridine-2-carbonitrile (2.15 g, 11.8 mmol) was dissolved in methanol (230 mL). 6 M hydrochloric acid (1 mL) and 10% palladium-carbon catalyst (234 mg) were added to the solution, followed by stirring the reaction mixture overnight under atmospheric hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to remove the solvent. Water was added to the residue and the resulting solution was freeze-dried to afford (5-(methylsulfonyl)pyridin-2-yl)methylamine hydrochloride as a yellow powder (2.34 g, 89% yield). The product was characterized by 1H NMR (CD3OD): δ 9.10 (1H, d, J = 2.2 Hz); 8.36 (1H, dd, J = 8.2, 2.4 Hz); 7.68 (1H, d, J = 8.8 Hz); 4.29 (2H, s); 3.22 (3H, s). | | References | [1] Patent: WO2005/26124, 2005, A1. Location in patent: Page/Page column 102
[2] Patent: WO2005/26123, 2005, A1. Location in patent: Page/Page column 86
[3] Patent: US2010/216843, 2010, A1. Location in patent: Page/Page column 22
[4] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0646
[5] Patent: WO2015/160654, 2015, A1 |
| | ([5-(Methylsulfonyl)Pyridin-2-Yl]Methyl)Amine Hydrochloride Preparation Products And Raw materials |
|