trans-4-(Methylamino)cyclohexanol hydrochloride manufacturers
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| | trans-4-(Methylamino)cyclohexanol hydrochloride Basic information | | Uses Application |
| | trans-4-(Methylamino)cyclohexanol hydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | White to off-white Solid |
| | trans-4-(Methylamino)cyclohexanol hydrochloride Usage And Synthesis |
| Uses | Trans-4-(methylamino)cyclohexanol hydrochloride can be used as a pharmaceutical synthesis intermediate, such as in the preparation of compounds for the formulation of Rho-kinase inhibitors. It can be used to treat diseases related to myosin light chain phosphatase phosphorylation inhibition. | | Application | trans-4-(methylamino)cyclohexanol hydrochloride can be used as a pharmaceutical synthesis intermediate. It can be prepared in one step from 2,2,2-trifluoro-N-(4-hydroxy-cyclohexyl)-N-methyl-acetamide. | | Synthesis | trans-4-(Methylamino)cyclohexanol hydrochloride was prepared as follows: 2 g of 2,2,2-trifluoro-N-(4-hydroxy-cyclohexyl)-N-methyl-acetamide (149) was suspended in 10 ml of 1NHCl and heated in a microwave oven at 150° until complete conversion. The resulting solution was lyophilized, and the residue was placed in water and lyophilized again for a total of two times to give 1.45 g of trans-4-(methylamino)cyclohexanol hydrochloride (150). rt = 0.13 min (Method C). Detected mass: 130.3 (M+H+).
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| | trans-4-(Methylamino)cyclohexanol hydrochloride Preparation Products And Raw materials |
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