Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane

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Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane Basic information
Product Name:Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane
Synonyms:Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane;2-?Azido-?6,?6-?bis[(2-?carboxyethoxy)?methyl]?-?8-?oxo-4,?11,?14,?17,?20-?pentaoxa-?7-?azadocosanoic Acid;N3-PEG4-amido-tri-(carboxyethoxymethyl)-methane
CAS:1398044-51-3
MF:C24H42N4O14
MW:610.61
EINECS:
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Mol File:1398044-51-3.mol
Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane Structure
Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane Chemical Properties
solubility Soluble in Water, DMSO, DMF
Safety Information
HS Code 2942000090
MSDS Information
Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane Usage And Synthesis
DescriptionAzido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane is a branched PEG linker with a terminal azide group and three terminal carboxylic acids. The azide group enables PEGylation via Click Chemistry.
UsesAzido-PEG4-amido-tri-(carboxyethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-amido-tri-(carboxyethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane Preparation Products And Raw materials
Tag:Azido-PEG4-Amido-tri-(carboxyethoxymethyl)-methane(1398044-51-3) Related Product Information
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