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| | Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane Basic information |
| | Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane Usage And Synthesis |
| Description | Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a branched PEGylation compound with a terminal azide group and three t-butyl groups. The t-butyl groups can be removed under acidic conditions. The azide group can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form stable triazole linkages. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | | Uses | Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane Preparation Products And Raw materials |
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