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EBELACTONE A manufacturers
- Ebelactone A
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2025-12-22
- CAS:76808-16-7
- Purity:
- Supply Ability: 10g
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| | EBELACTONE A Basic information |
| Product Name: | EBELACTONE A | | Synonyms: | 4-(8-hydroxy-1,3,5,7,9-pentamethyl-6-oxo-3-undecenyl)-3-methyl-2-oxetanon(;4-beta(1r*,3e,5s*,7r*,8s*,9s*)))-3s-(3-alph;EBELACTONE A;3,11-DIHYDROXY-2,4,5,6,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE;3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECANOIC-1,3-LACTONE;3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECEN-3-OLIDE;3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE;3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC ACID 1,3-LACTONE | | CAS: | 76808-16-7 | | MF: | C20H34O4 | | MW: | 338.48 | | EINECS: | | | Product Categories: | | | Mol File: | 76808-16-7.mol |  |
| | EBELACTONE A Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml | | form | White crystalline powder. | | biological source | Streptomyces sp. |
| WGK Germany | 3 | | RTECS | RQ7730000 |
| | EBELACTONE A Usage And Synthesis |
| Description | Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08 μg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function. | | Uses | Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively[1]. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis[2]. | | References | [1] Umezawa H, et al., Ebelactone, an inhibitor of esterase, produced by actinomycetes. J Antibiot (Tokyo). 1980 Dec;33(12):1594-6. DOI:10.7164/antibiotics.33.1594
[2] Francis S A, et al., The role of cutinase in germling development and infection byErysiphe graminisf. sp. hordei[J]. Physiological and Molecular Plant Pathology, 1996, 49(3): 201-211. |
| | EBELACTONE A Preparation Products And Raw materials |
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