1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-

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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Suppliers list
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
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Products Intro: Product Name:1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
CAS:116409-29-1
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:NSC 370284
CAS:116409-29-1
Package:1 mg；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
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Products Intro: Product Name:NSC-370284
CAS:116409-29-1
Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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Products Intro: Product Name:NSC370284
CAS:116409-29-1
Purity:0.98 Package:100mg;500mg;1g;5g Remarks:existing product
Company Name: Aladdin Scientific
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Products Intro: Product Name:NSC-370284
CAS:116409-29-1
Purity:96% Package:$80.9/5mg;$150.9/10mg;$320.9/25mg;$540.9/50mg;$940.9/100mg;Bulk package Remarks:96%
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Basic information
Product Name:1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
Synonyms:1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-;NSC 370284;NSC 370284, 10 mM in DMSO
CAS:116409-29-1
MF:C21H25NO6
MW:387.43
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Mol File:116409-29-1.mol
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Structure
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Chemical Properties
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Usage And Synthesis
UsesNSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].
in vivo

NSC-370284 (2.5 mg/kg; i.p., once daily for 10 days) improves the pathological morphologies in peripheral blood (PB), bone marrow (BM), spleen, and liver tissues in MLL-AF9 acute myeloid leukemia (AML) mice model[1].

Animal Model:C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice[1].
Dosage:2.5mg/kg.
Administration:Intraperitoneal injection, once daily, for 10 days.
Result:Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.
IC 50STAT3; STAT5; TET1
References[1] Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099. DOI:10.1038/s41467-017-02290-w
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Preparation Products And Raw materials
Raw materials3,4,5-Trimethoxybenzaldehyde-->Sesamol-->Pyrrolidine
Tag:1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-(116409-29-1) Related Product Information