BAY-1163877 manufacturers
- Rogaratinib
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- $64.00
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2026-05-11
- CAS:1443530-05-9
- Purity: 99.61%
- Supply Ability: 10g
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| | BAY-1163877 Basic information |
| Product Name: | BAY-1163877 | | Synonyms: | BAY-1163877;4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f]-[1,2,4]triazin-7-yl]methyl}piperazin-2-one;Rogaratinib (BAY1163877);2-Piperazinone, 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]-;Rogaratinib,inhibit,BAY 1163877,Fibroblast growth factor receptor,BAY-1163877,FGFR,Inhibitor;Rogaratinib | | CAS: | 1443530-05-9 | | MF: | C23H26N6O3S | | MW: | 466.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1443530-05-9.mol |  |
| | BAY-1163877 Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:5.0(Max Conc. mg/mL);10.72(Max Conc. mM) | | form | Solid | | pka | 15.49±0.20(Predicted) | | color | White to light yellow |
| | BAY-1163877 Usage And Synthesis |
| Uses | Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib inhibits FGFRs with IC50s of 11.2 nM (FGFR1), <1 nM (FGFR2), 18.5 nM (FGFR3), 127 nM (VEGFR3/FLT4), 201 nM (FGFR4), respectively[1][2]. | | IC 50 | FGFR1; FGFR2; FGFR3; FGFR4 | | References | [1] Heroult M, et al. Preclinical profile of BAY 1163877-a selective pan-FGFR inhibitor in phase 1 clinical trial[J]. Cancer Res, 2014, 74(suppl 19): 1739a.
[2] Kim SM, et al. Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy. Oncogenesis. 2016 Jul 18;5(7):e241. DOI:10.1038/oncsis.2016.48 |
| | BAY-1163877 Preparation Products And Raw materials |
| Raw materials | 6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine-->ETHYL 4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZINE-6-CARBOXYLATE-->Pyrrolo[2,1-f][1,2,4]triazine-6-methanol, 4-amino--->Benzenethiol, 2-methoxy-4-methyl--->7-Methoxy-5-Methylbenzo[b]thiophene-->(7-Methoxy-5-Methylbenzo[b]thiophen-2-yl)boronic acid-->2-Piperazinone-->2-methoxy-p-toluidine-->(2,2-diethoxyethyl)(2-methoxy-4-methylphenyl)sulfane-->2-METHOXY-4-METHYLBENZENESULFONYL CHLORIDE-->4-AMinopyrrolo[1,2-f][1,2,4]triazine-6-carbonitrile-->5-METHYL-2-NITROANISOLE-->Formaldehyde |
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