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| | Benzyloxy carbonyl-PEG3-NHS ester Basic information |
| | Benzyloxy carbonyl-PEG3-NHS ester Chemical Properties |
| Boiling point | 559.0±60.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF |
| | Benzyloxy carbonyl-PEG3-NHS ester Usage And Synthesis |
| Description | Benzyloxy carbonyl-PEG3-NHS ester is a PEG linker which contains a benzyl protecting group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The benzyl protecting group can be removed by hydrogenolysis. The PEG linker increases the compounds water solubility in aqueous media. | | Uses | Benzyloxy carbonyl-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Benzyloxy carbonyl-PEG3-NHS ester Preparation Products And Raw materials |
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