N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester

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N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester Basic information
Product Name:N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester
Synonyms:N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester;(N3-PEG3)(Boc)-N-PEG3-COOtBu;Boc-(N3-PEG3-CH2CH2)N-PEG3-CH2CH2COOtBu
CAS:2112732-03-1
MF:C26H50N4O10
MW:578.696
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Mol File:2112732-03-1.mol
N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester Structure
N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester Chemical Properties
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N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester Usage And Synthesis
DescriptionN-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a protected multifunction linker. The azide group enables PEGylation via Click Chemistry. Boc and the t-butyl protected carboxyl group can be deprotected under mild acidic conditions.
UsesN-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester Preparation Products And Raw materials
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