N-(Azido-PEG3)-N-Boc-PEG3-acid manufacturers
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| | N-(Azido-PEG3)-N-Boc-PEG3-acid Basic information |
| Product Name: | N-(Azido-PEG3)-N-Boc-PEG3-acid | | Synonyms: | N-(Azido-PEG3)-N-Boc-PEG3-acid;CUN 31527;5,8,11-Trioxa-2-azatetradecanedioic acid, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-, 1-(1,1-dimethylethyl) ester;Boc-(N3-PEG3-CH2CH2)N-PEG3-CH2CH2COOH;1-Azido-12-(tert-butoxycarbonyl)-3,6,9,15,18,21-hexaoxa-12-azatetracosan-24-oic acid | | CAS: | 2112731-52-7 | | MF: | C22H42N4O10 | | MW: | 522.58968 | | EINECS: | | | Product Categories: | | | Mol File: | 2112731-52-7.mol |  |
| | N-(Azido-PEG3)-N-Boc-PEG3-acid Chemical Properties |
| | N-(Azido-PEG3)-N-Boc-PEG3-acid Usage And Synthesis |
| Description | N-(Azido-PEG3)-N-Boc-PEG3-acid enable Click Chemistry with alkyne such as Propargyl, BCN or DBCO reagent. Boc group can be deprotected under acidic conditions. The terminal carboxylic acid can react with primary amino groups in the presence of EDCor HATU. | | Uses | N-(Azido-PEG3)-N-Boc-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Boc-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Azido-PEG3)-N-Boc-PEG3-acid Preparation Products And Raw materials |
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