| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
SALOR-INT L224693-1EA manufacturers
- FDI-6
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- $31.00
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2026-08-20
- CAS:313380-27-7
- Purity: 99.39%
- Supply Ability: 10g
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| | SALOR-INT L224693-1EA Basic information |
| Product Name: | SALOR-INT L224693-1EA | | Synonyms: | SALOR-INT L224693-1EA;3-AMINO-N-(4-FLUOROPHENYL)-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE;3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide;3-Amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-fluoro-phenyl)-amide;FDI 6;FDI 6 - NCGC 00099374;Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)-;FDI-6 >=98% (HPLC) | | CAS: | 313380-27-7 | | MF: | C19H11F4N3OS2 | | MW: | 437.43 | | EINECS: | | | Product Categories: | | | Mol File: | 313380-27-7.mol |  |
| | SALOR-INT L224693-1EA Chemical Properties |
| Boiling point | 533.7±50.0 °C(Predicted) | | density | 1.562±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO:64.34(Max Conc. mg/mL);147.09(Max Conc. mM) | | form | powder (flocculent) | | pka | 10.24±0.70(Predicted) | | color | white to beige | | InChI | 1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27) | | InChIKey | ZATJMMZPGVDUOM-UHFFFAOYSA-N | | SMILES | NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | SALOR-INT L224693-1EA Usage And Synthesis |
| Uses | FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. | | Biochem/physiol Actions | Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production. In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration. | | References | [1] Gormally MV, et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165. DOI:10.1038/ncomms6165 |
| | SALOR-INT L224693-1EA Preparation Products And Raw materials |
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