(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1

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(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 Basic information
Product Name:(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1
Synonyms:(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1;Retagliptin Hydrochloride
CAS:1174038-86-8
MF:C19H19ClF6N4O3
MW:500.8225792
EINECS:
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Mol File:1174038-86-8.mol
(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 Structure
(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 Chemical Properties
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MSDS Information
(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 Usage And Synthesis
UsesRetagliptin (SP2086) hydrochloride is a potent inhibitor of beta-amino acids and dipeptidyl peptidase-4 (DPP-4). Retagliptin (SP2086) hydrochloride inhibits type 2 diabetes and improves glycemic control by prolonging the action of intestinal hormones such as glucagon-like peptide-1 (GLP-1)[1].
References[1] Kim GH, et al. Enzymatic synthesis of sitagliptin intermediate using a novel ω-transaminase. Enzyme Microb Technol. 2019 Jan;120:52-60. DOI:10.1016/j.enzmictec.2018.10.003
(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 Preparation Products And Raw materials
Tag:(R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1(1174038-86-8) Related Product Information
Retagliptin (R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1- carboxylic acid methyl ester (R)-methyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1 CD26/DIPEPTIDYL PEPTIDASE 4 PROTEIN, MOUSE (HEK293, FC) Sitagliptin GCGR/Glucagon receptor Protein, Mouse (HEK293, Fc)