|
|
| | Ac-Leu-Val-Lys-aldehyde Basic information |
| Product Name: | Ac-Leu-Val-Lys-aldehyde | | Synonyms: | CATHEPSIN B INHIBITOR II;AC-LEU-VAL-L-LYSINAL;AC-LVK-CHO;L-Valinamide, N-acetyl-L-leucyl-N-[(1S)-5-amino-1-formylpentyl]-;Ac-Leu-Val-Lys-aldehyde | | CAS: | 147600-40-6 | | MF: | C19H36N4O4 | | MW: | 384.51 | | EINECS: | | | Product Categories: | | | Mol File: | 147600-40-6.mol |  |
| | Ac-Leu-Val-Lys-aldehyde Chemical Properties |
| Boiling point | 665.5±55.0 °C(Predicted) | | density | 1.059±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | water: 1 mg/mL | | pka | 13.43±0.46(Predicted) | | form | solid | | color | white | | Water Solubility | water: 1mg/mL | | Sequence | Ac-Leu-Val-{Lys-Aldehyde} |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Ac-Leu-Val-Lys-aldehyde Usage And Synthesis |
| Uses | Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1]. | | Biological Activity | Cell permeable: no', 'Primary Target
cathepsin B', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 4 nM against cathepsin B | | IC 50 | Cathepsin B: 4 nM (IC50) | | References | [1] McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. DOI:10.1021/jm00060a016
[2] Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702. DOI:10.1371/journal.pone.0075702 |
| | Ac-Leu-Val-Lys-aldehyde Preparation Products And Raw materials |
|