N-Desmethyl zopiclone

Request For Quotation
N-Desmethyl zopiclone Suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532 18210857532
Email: jkinfo@jkchemical.com
Company Name: Chemsky（shanghai）International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Company Name: Artis Chemistry (Shanghai) Co. Ltd.  
Tel: 86-21-60936353
Email:
Company Name: Clearsynth Labs Limited  
Tel: +91-22-26355700
Email: info@clearsynth.com
Company Name: Cato Research Chemicals Inc.  
Tel: 020-81960175
Email: min.he@cato-chem.com
N-Desmethyl zopiclone Basic information
Product Name:N-Desmethyl zopiclone
Synonyms:N-Desmethyl Zopiclone Hydrochloride;Piperazine -1-carboxylic Acid 6-(5-Chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5yl Ester Hydrochloride;6-(5-CHLOROPYRIDIN-2-YL)-7-OXO-6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRAZIN-5-YL PIPERAZINE-1-CARBOXYLATE;Desmethylzopiclone;1-Piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester;6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxyl;Norzopiclone;N-Desmethyl zopiclone Solution, 100ppm
CAS:59878-63-6
MF:C16H15ClN6O3
MW:374.78
EINECS:
Product Categories:Isotopically Labeled Pharmaceutical Reference Standard;Heterocycles;GABA/Glycine receptor;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:59878-63-6.mol
N-Desmethyl zopiclone Structure
N-Desmethyl zopiclone Chemical Properties
Melting point 226-2280C
Boiling point 599.0±50.0 °C(Predicted)
density 1.57±0.1 g/cm3(Predicted)
Fp 2°C
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form Solid
pka8.26±0.10(Predicted)
color White to Off-White
Safety Information
RIDADR UN 1648 3 / PGII
WGK Germany 2
MSDS Information
N-Desmethyl zopiclone Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
UsesA metabolite of Zopiclone (Z700500).
UsesN-Desmethyl Zopiclone is a metabolite of Zopiclone (Z700500), N-Desmethyl Zopiclone is an intermediate in the synthesis of N-Desmethyl Zopiclone Hydrochloride (D296770).
in vivo

A demethylation metabolic pathway produces Norzopiclone (N-desmethylzopiclone), a metabolite which reportedly accounts for 15% of an oral dose of racemic Zopiclone, and which is also reportedly inactive[2]. N-oxide-Zopiclone has a similar t1/2 compared to parent Zopiclone, while the t1/2 of Norzopiclone (N-desmethyl-Zopiclone) ranges from 7 to 11 h[3].

N-Desmethyl zopiclone Preparation Products And Raw materials
Tag:N-Desmethyl zopiclone(59878-63-6) Related Product Information
N-Desmethyl zopiclone-d8 (S)-(+)-N-Desmethyl zopiclone-d8 (S)-(+)-N-Desmethyl zopiclone N-Desmethyl zopiclone Zopiclone N-oxide N-Desmethyl zopiclone-d4 Zopiclone N-Desmethyl Zopiclone-d8 Hydrochloride Eszopiclone Eszopiclone N-Oxide