葫芦巴碱
| 中文名称 | 葫芦巴碱 |
|---|---|
| 中文同义词 | 葫蘆巴鹼;菸鹼酸N-甲內鹽;N-甲菸鹼酸內鹽;烟酸甜菜碱;葫芦巴碱;1-甲基吡啶鎓-3-甲酸内盐;1-甲基吡啶-3-甲酸内盐;葫芦巴碱 (1-甲基吡啶鎓-3-甲酸内盐 |
| 英文名称 | Trigonelline |
| 英文同义词 | betainnicotinate;Caffearine;Coffearin;Coffearine;Gynesine;n’-methylnicotinicacid;Nicotinic acid N-methylbetaine;nicotinicacidn-methylbetaine |
| CAS号 | 535-83-1 |
| 分子式 | C7H7NO2 |
| 分子量 | 137.14 |
| EINECS号 | 208-620-5 |
| 植物来源 | 葫芦巴 |
| 相关类别 | 小分子抑制剂;对照品;小分子抑制剂，天然产物;分析试剂标准品;分析对照品;中药对照品;标准品;对照品,标准品;植物提取物;标准提取物;标准品-对照品;标准品-中药标准品;其他原料;标准品 -中药标准品;标准品，对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;食品原料;通用生化试剂-有机酸;标准提取物 |
| Mol文件 | 535-83-1.mol |
| 结构式 |  |
葫芦巴碱 性质
| 熔点 | 260°C (dec.) |
|---|---|
| 沸点 | 251.96°C (rough estimate) |
| 密度 | 1.2528 (rough estimate) |
| 折射率 | 1.5030 (estimate) |
| 储存条件 | Refrigerator |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 灰白色至浅米色 |
| 主要应用 | pharmaceutical (small molecule) |
| InChI | InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3 |
| InChIKey | WWNNZCOKKKDOPX-UHFFFAOYSA-N |
| SMILES | C1(C([O-])=O)=CC=C[N+](C)=C1 |
| LogP | -3.910 (est) |
| Target | Value |
|
PLCγ1
() | |
|
PI3K
() | |
|
Akt
() | |
|
microtubule
() |
It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .
Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
药理药效:为胡芦巴中的主要成分，具有抗肿瘤作用。
安全信息
| 安全说明 | 24/25 |
|---|---|
| WGK Germany | WGK 3 |
| TSCA | TSCA listed |
| 海关编码 | 29339900 |
| 存储类别 | 13 - 不可燃性固体 |
| 毒害物质数据 | 535-83-1(Hazardous Substances Data) |