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| | 2H-1,2,3 Triazole-2-acetic acid Basic information |
| | 2H-1,2,3 Triazole-2-acetic acid Chemical Properties |
| Boiling point | 344.0±44.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2+-.0.10(Predicted) | | Appearance | Off-white to light yellow Solid |
| | 2H-1,2,3 Triazole-2-acetic acid Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2H-2-acetic acid-1,2,3-triazole-1,2,3-triazole from ethyl 2-(2H-1,2,3-triazol-2-yl)acetate was as follows:
1. Preparation of 2H-1,2,3-triazol-2-ylacetic acid: a solution of lithium hydroxide monohydrate (2.5 g, 60 mmol) in water (15 mL) was added to a solution of ethyl 2-(2H-1,2,3-triazol-2-yl)acetate (7.8 g, 50 mmol), and the reaction was stirred for 18 h at room temperature.
2. Upon completion of the reaction, the reaction mixture was acidified with 2M hydrochloric acid (150 mL) followed by extraction with dichloromethane (150 mL x 3).
3. The organic phases were combined, dried over magnesium sulfate and concentrated under reduced pressure to afford 2H-2-acetic acid-1,2,3-triazole as a white solid in 81% (5.2 g) yield. 4.
4. Product characterization: 1H NMR (400 MHz, CDCl3) δ: 5.35 (s, 2H), 7.72 (s, 2H); LRMS APCI m/z 128 [M + H]+. | | References | [1] Patent: WO2006/123242, 2006, A1. Location in patent: Page/Page column 35 |
| | 2H-1,2,3 Triazole-2-acetic acid Preparation Products And Raw materials |
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