7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione
| 中文名称 | 7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione |
|---|---|
| 中文同义词 | 化合物 T15387;GLP-1R拮抗剂1;GLP-1R拮抗剂1,10 MM DMSO 溶液 |
| 英文名称 | 7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione |
| 英文同义词 | 7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione;VU 0650991;GLP-1R Antagonist 1;Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, 7-(4-chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)-;GLP 1R Antagonist 1,GLP1R Antagonist 1;GLP-1R Antagonist 1, 10 mM in DMSO |
| CAS号 | 488097-06-9 |
| 分子式 | C16H11ClF6N4O2 |
| 分子量 | 440.7275592 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 488097-06-9.mol |
| 结构式 | ![7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione 结构式](CAS/20180720/GIF/488097-06-9.gif) |
7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
7-(4-chlorophenyl)-1,3-dimethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione 用途与合成方法
GLP-1R Antagonist 1 (compound 5d) 是口服有效的、能透过中枢神经系统的，胰高血糖素样肽 1 受体 (GLP-1R) 的非竞争性拮抗剂，其IC50 值为 650 nM。