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| | ABO (hydrochloride) Basic information |
| | ABO (hydrochloride) Chemical Properties |
| solubility | DMF: 2 mg/ml
DMSO: 2 mg/ml
Ethanol: 5 mg/mlPBS (pH 7.2): 5 mg/ml | | form | Solid | | color | Brown to black |
| | ABO (hydrochloride) Usage And Synthesis |
| Uses | ABO hydrochloride is a potent modulator of ANXA7 as ABO binds to Thr286 of ANXA7 and inhibits its phosphorylation. ABO promotes autophagy via elevation of ANXA7 and triggering ANXA7 subcellular redistribution[1]. | | References | [1] Li H, et al. Identification of a small molecule targeting annexin A7. Biochim Biophys Acta. 2013 Sep;1833(9):2092-9. DOI:10.1016/j.bbamcr.2013.04.015
[2] H LI. Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E−/− mice[J]. Cell Death & Disease, 2013, 4 9: e806-e806. DOI: 10.1038/cddis.2013.317 |
| | ABO (hydrochloride) Preparation Products And Raw materials |
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