MCH (human, mouse, rat) (trifluoroacetate salt)

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MCH (human, mouse, rat) (trifluoroacetate salt) Suppliers list
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
MCH (human, mouse, rat) (trifluoroacetate salt) Basic information
Product Name:MCH (human, mouse, rat) (trifluoroacetate salt)
Synonyms:MCH (human, mouse, rat) (trifluoroacetate salt)
CAS:
MF:C105H160N30O26S4
MW:2386.8393
EINECS:
Product Categories:
Mol File:Mol File
MCH (human, mouse, rat) (trifluoroacetate salt) Structure
MCH (human, mouse, rat) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
Safety Information
MSDS Information
MCH (human, mouse, rat) (trifluoroacetate salt) Usage And Synthesis
DescriptionMelanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors.1 It binds to MCH1 and MCH2 receptors (IC50s = 0.17 and 2.9 nM, respectively, for the human receptors) and stimulates calcium accumulation with EC50 values of 28 and 50 nM, respectively, in an aequorin bioluminescence functional assay. MCH also binds to the rat MCH1 receptor (Ki = 0.16 nM in CHO cells), stimulates calcium accumulation (EC50 = 1.79 nM), and inhibits intracellular cAMP accumulation induced by forskolin (Item No. 11018; EC50 = 0.46 nM).2 It binds to mouse MCH receptors on melanoma B16 cells (Ki = 33 nM) and dose-dependently activates the mitogen-activated protein kinase (MAPK) signaling pathway.3 MCH (5 nmol/kg, i.c.v.) increases cumulative food intake in rats.2WARNING This product is not for human or veterinary use.
References[1] M. BEDNAREK. Synthesis and Biological Evaluation in Vitro of a Selective, High Potency Peptide Agonist of Human Melanin-concentrating Hormone Action at Human Melanin-concentrating Hormone Receptor 1*[J]. The Journal of Biological Chemistry, 2002, 44 1: 13821-13826. DOI: 10.1074/jbc.m200563200
[2] MAULON-FERAILLE L, ZUANA O D, SUPLY T, et al. Appetite-boosting property of pro-melanin-concentrating hormone(131-165) (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance.[J]. The Journal of Pharmacology and Experimental Therapeutics, 2002, 302 2 1: 0. DOI: 10.1124/jpet.302.2.766
[3] SOPHIE E SCHLUMBERGER. Different structural requirements for melanin-concentrating hormone (MCH) interacting with rat MCH-R1 (SLC-1) and mouse B16 cell MCH-R.[J]. Journal of Receptors and Signal Transduction, 2003, 23 1: 69-81. DOI: 10.1081/rrs-120018761
MCH (human, mouse, rat) (trifluoroacetate salt) Preparation Products And Raw materials
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