| Company Name: |
BOC Sciences |
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+1-631-485-4226 |
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Foretinib-Based PROTAC 7 manufacturers
- SJF 8240
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- $1060.00
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2026-07-27
- CAS:2230821-68-6
- Purity:
- Supply Ability: 10g
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| | Foretinib-Based PROTAC 7 Basic information |
| Product Name: | Foretinib-Based PROTAC 7 | | Synonyms: | Foretinib-Based PROTAC 7;1-N'-[3-fluoro-4-[7-[3-[3-[3-[[(2R)-1-[(2R,4S)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]propoxy]propoxy]-6-methoxyquinolin-4-yl]oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;N'1-{3-fluoro-4-[(7-{3-[3-(2-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)propoxy]propoxy}-6-methoxyquinolin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;N-[(1S)-2-[(5S,3R)-3-Hydroxy-5-[N-[[4-[4-methyl(1,3-thiazol-5-yl)]phenyl]methyl]carbamoyl]pyrrolidinyl]-1-(tert-butyl)-2-oxoethyl]-3-[3-[3-[4-[2-fluoro-4-[[[N-(4-fluorophenyl)carbamoyl]cyclopropyl]carbonylamino]phenoxy]-6-methoxy(7-quinolyloxy)]propoxy]propoxy]propanamide | | CAS: | 2230821-68-6 | | MF: | C58H65F2N7O11S | | MW: | 1106.25 | | EINECS: | | | Product Categories: | | | Mol File: | 2230821-68-6.mol |  |
| | Foretinib-Based PROTAC 7 Chemical Properties |
| Boiling point | 1226.5±65.0 °C(Predicted) | | density | 1.341±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO|55.31|50| | | pka | 13.14±0.70(Predicted) | | form | Solid | | color | White to light yellow |
| | Foretinib-Based PROTAC 7 Usage And Synthesis |
| Description | SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells. | | Uses | SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. SJF-8240 induces polyubiquitination of c-Met and inhibits the proliferation of GTL16 cells (IC50=66.7 nM)[1]. | | storage | Store at -20°C | | References | [1] Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. DOI:10.1016/j.chembiol.2017.09.009 |
| | Foretinib-Based PROTAC 7 Preparation Products And Raw materials |
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