GNE-6468

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Company Name: BOC Sciences  
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GNE-6468 manufacturers

  • GNE-6468
  • GNE-6468 pictures
  • $943.00
  • 2026-07-10
  • CAS:1677668-27-7
  • Purity: 99.73%
  • Supply Ability: 10g
GNE-6468 Basic information
Product Name:GNE-6468
Synonyms:GNE-6468;Benzoic acid, 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxy-;GNE 6468,GNE6468
CAS:1677668-27-7
MF:C23H16ClN3O4
MW:433.84
EINECS:
Product Categories:
Mol File:1677668-27-7.mol
GNE-6468 Structure
GNE-6468 Chemical Properties
density 1.55±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 5 mg/mL (11.52 mM)
pka2.35±0.10(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
GNE-6468 Usage And Synthesis
DescriptionGNE-6468 is a potent and selective RORc inverse agonist. GNE-6468 displayed >300-fold selectivity for RORc over the other ROR family members, PPARγ, and NRs in our cellular selectivity panel. The favorable potency, selectivity, and physiochemical properties of GNE-6468, in addition to its potent suppression of IL-17 production in human primary cells, support its use as chemical biology tools to further explore the role of RORc in human biology. The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORγ, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine interleukin-17.
UsesGNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC[1].
in vivo

GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CLhep = 17 and 42 mL/min/kg, respectively) [1].

IC 50ROR-γ: 2 nM (EC50)
References[1] Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12. DOI:10.1016/j.bmcl.2015.05.055
GNE-6468 Preparation Products And Raw materials
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