| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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| Product Name: | Pep2-8 | | Synonyms: | Pep2-8;(3S,6S,9S,12S,15S)-15-((2S,5S,8S,11S,14S,17S)-2-((1H-Indol-3-yl)methyl)-11-benzyl-8,17-bis((R)-1-hydroxyethyl)-5-(hydroxymethyl)-14-isopropyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosanamido)-3-(((S)-1-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-12-(2-carboxyethyl)-9-(4-hydroxybenzyl)-6-isobutyl-5,8,11,14-tetraoxo-4,7,10,13-tetraazaoctadecane-1,18-dioic acid;(3S,6S,9S,12S,15S)-15-((2S,5S,8S,11S,14S,17S)-2-((1H-Indol-3-yl)methyl)-11-benzyl-8,17-bis((R)-1-hydroxyethyl)-5-(hydroxymethyl)-14-isopropyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosanamido)-3-(((S)-1-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)amino | | CAS: | 1541011-97-5 | | MF: | C83H110N16O24 | | MW: | 1715.88 | | EINECS: | | | Product Categories: | | | Mol File: | 1541011-97-5.mol |  |
| | Pep2-8 Chemical Properties |
| Boiling point | 2059.4±65.0 °C(Predicted) | | density | 1.357±0.06 g/cm3(Predicted) | | storage temp. | store at -20°C, protect from light | | solubility | Soluble 2mg/mL in PBS (pH 7.4) | | form | A solid | | pka | 4.20±0.10(Predicted) | | color | White to off-white | | Sequence | Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 |
| | Pep2-8 Usage And Synthesis |
| Uses | Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM[1]. | | storage | Store at -20°C | | References | [1] Yingnan Zhang, et al. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem. 2014 Jan 10;289(2):942-55. DOI:10.1074/jbc.M113.514067 |
| | Pep2-8 Preparation Products And Raw materials |
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