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| | Mono-tert-butyl docosanedioate Basic information |
| Product Name: | Mono-tert-butyl docosanedioate | | Synonyms: | Docosanedioic acid, 1-(1,1-dimethylethyl) ester;Docosanedioic acid, mono(1,1-dimethylethyl) ester;22-(tert-butoxy)-22-oxoicosanoic acid;Mono-tert-butyl docosanedioate;22-(tert-Butoxy)-22-oxodocosanoic acid | | CAS: | 1642333-05-8 | | MF: | C26H50O4 | | MW: | 426.67 | | EINECS: | | | Product Categories: | | | Mol File: | 1642333-05-8.mol |  |
| | Mono-tert-butyl docosanedioate Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | powder | | color | White | | InChI | InChI=1S/C26H50O4/c1-26(2,3)30-25(29)23-21-19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20-22-24(27)28/h4-23H2,1-3H3,(H,27,28) | | InChIKey | OXPWLSZVTHVKQN-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCCCCCC(O)=O |
| | Mono-tert-butyl docosanedioate Usage And Synthesis |
| Uses | 22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t | | IC 50 | Non-cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | Mono-tert-butyl docosanedioate Preparation Products And Raw materials |
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