4-Hydroxy 4-Dedimethylamino Afatinib 基本信息
| 中文名称 | 4-Hydroxy 4-Dedimethylamino Afatinib |
|---|---|
| 中文同义词 | 马来酸阿法替尼杂质3;(2E)-N-[4-[(3-氯-4-氟苯基)氨基]-7-[[(3S)-四氢-3-呋喃基]氧基]-6-喹唑啉基]-4-羟基-2-丁烯酰胺;阿法替尼-4-羟基杂质;阿伐替尼相关杂质 |
| 英文名称 | 4-Hydroxy 4-Dedimethylamino Afatinib |
| 英文同义词 | 4-Hydroxy 4-Dedimethylamino Afatinib;Afatinib impurity 2/4-Hydroxy 4-Dedimethylamino Afatinib/(2E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-hydroxy-2-butenamide;Afatinib 4-Hydroxy Analog;Afatinib Maleate Acid Impurity 3;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-hydroxy-, (2E)-;(2E)?-N-?[4-?[(3-?chloro-?4-?fluorophenyl)?amino]?-?7-?[[(3S)?-?tetrahydro-?3-?furanyl]?oxy]?-?6-?quinazolinyl]?-?4-?hydroxy-2-?butenamide;1,3-dimethyl-52-nitrosourea;Lansoprazole Impurity 73 |
| CAS号 | 2121530-37-6 |
| 分子式 | C22H20ClFN4O4 |
| 分子量 | 458.87 |
| EINECS号 | |
| 相关类别 | 杂质 |
| Mol文件 | 2121530-37-6.mol |
| 结构式 |  |
4-Hydroxy 4-Dedimethylamino Afatinib 性质
| 沸点 | 714.713±60.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| 密度 | 1.484±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 酸度系数(pKa) | 11.521±0.43(predicted) |
| InChIKey | XZMUSENASPIMAT-YUKKFKLSSA-N |
| SMILES | N(C1C=CC(=C(C=1)Cl)F)C1=NC=NC2C=C(C(=CC=21)NC(=O)/C=C/CO)O[C@@H]1COCC1 |