- VL285
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- $50.00
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2026-07-13
- CAS:1448188-57-5
- Purity: 99.85%
- Supply Ability: 10g
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| Product Name: | VL285 | | Synonyms: | VL285;VL-285; VL 285; VL285;2-Pyrrolidinecarboxamide, 1-[(2S)-2-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-methyl-1-oxobutyl]-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (2S,4R)-;(2S,4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-1-[(2S)-3-methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoyl]pyrrolidine-2-carboxamide;(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;E3 ligase-recruiting Moiety,VL-285,Ligands for E3 Ligase,Inhibitor,inhibit,VL285,VL 285;VL285, 10 mM in DMSO | | CAS: | 1448188-57-5 | | MF: | C29H32N4O4S | | MW: | 532.65 | | EINECS: | | | Product Categories: | | | Mol File: | 1448188-57-5.mol |  |
| | VL285 Chemical Properties |
| storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml | | form | Solid | | color | White to off-white |
| | VL285 Usage And Synthesis |
| Uses | VL285 is a potent VHL ligand with an IC50 of 0.34 μM[1]. | | IC 50 | VHL | | References | [1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442 |
| | VL285 Preparation Products And Raw materials |
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