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| | Boc-AEVD-CHO (trifluoroacetate salt) Basic information |
| | Boc-AEVD-CHO (trifluoroacetate salt) Chemical Properties |
| | Boc-AEVD-CHO (trifluoroacetate salt) Usage And Synthesis |
| Description | Boc-AEVD-CHO is an inhibitor of caspase-8 (Ki = 1.6 nM) that also inhibits caspase-1, -3, -6, and -9 (Kis = <12, 42, 52, and 48 nM, respectively).1 It is selective for these caspases over caspase-2, -4, -5, -7, and -10 (Kis = >10,000, 375, 438, 425, and 320 nM, respectively). Boc-AEVD-CHO has been used to study the potential interference of caspase-8 activity in micronuclei detection.2 It inhibits apoptosis induced by the aneugen nocodazole (Item No. 13857) in isolated human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 300 µM.WARNING This product is not for human or veterinary use. | | References | [1] M GARCIA-CALVO. Inhibition of human caspases by peptide-based and macromolecular inhibitors.[J]. The Journal of Biological Chemistry, 1998, 273 49: 32608-32613. DOI: 10.1074/jbc.273.49.32608
[2] ILSE DECORDIER Micheline K V Enrico Cundari. Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation.[J]. Mutagenesis, 2005, 20 3: 173-179. DOI: 10.1093/mutage/gei025 |
| | Boc-AEVD-CHO (trifluoroacetate salt) Preparation Products And Raw materials |
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