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| | Azidoethyl-PEG2-t-Butyl ester Basic information |
| | Azidoethyl-PEG2-t-Butyl ester Chemical Properties |
| | Azidoethyl-PEG2-t-Butyl ester Usage And Synthesis |
| Description | Azidoethyl-PEG2-t-Butyl ester is a PEG linker that contains a cleavable disulfide bond, an azide group and a t-butyl ester group. The disulfide bond can be cleaved via reduction reactions. The azide group can be reacted with an alkyne, DBCO or BCN moiety to undergo copper-catalyzed Click Chemistry. The t-butyl ester group can be removed under acidic conditions. | | Uses | Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azidoethyl-SS-PEG2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azidoethyl-PEG2-t-Butyl ester Preparation Products And Raw materials |
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