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| | Azido-PEG9-t-butyl ester Basic information |
| Product Name: | Azido-PEG9-t-butyl ester | | Synonyms: | Azido-PEG9-t-butyl ester;Azido-PEG10-t-butyl ester;CAS_1818294-43-7;Azido-PEG9-COOtBu;Azido-PEG9-Boc;Azido-PEG9-tBu Ester;4,7,10,13,16,19,22,25,28-Nonaoxatriacontanoic acid, 30-azido-, 1,1-dimethylethyl ester;tert-Butyl 1-azido-3,6,9,12,15,18,21,24,27-nonaoxatriacontan-30-oate | | CAS: | 1818294-43-7 | | MF: | C25H49N3O11 | | MW: | 567.68 | | EINECS: | | | Product Categories: | | | Mol File: | 1818294-43-7.mol |  |
| | Azido-PEG9-t-butyl ester Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | Azido-PEG9-t-butyl ester Usage And Synthesis |
| Description | Azido-PEG9-t-butyl ester is a PEG linker molecule with an azide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The PEG9 spacer increases solubility in aqueous media. | | Uses | Azido-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG9-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG9-t-butyl ester Preparation Products And Raw materials |
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