| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
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| | ELA-11 (human) Basic information |
| Product Name: | ELA-11 (human) | | Synonyms: | ELA-11 (human);L-Proline, L-cysteinyl-L-methionyl-L-prolyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-phenylalanyl- | | CAS: | 1784687-32-6 | | MF: | C58H90N16O13S2 | | MW: | 1283.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1784687-32-6.mol |  |
| | ELA-11 (human) Chemical Properties |
| density | 1.47±0.1 g/cm3(Predicted) | | form | Solid | | pka | 3.43±0.20(Predicted) | | color | White to off-white | | Sequence | Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro |
| | ELA-11 (human) Usage And Synthesis |
| Uses | ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1]. | | References | [1] Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173. DOI:10.1161/CIRCULATIONAHA.116.023218 |
| | ELA-11 (human) Preparation Products And Raw materials |
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