BAY-218 manufacturers
- BAY-218
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- $34.00 / 1mg
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2026-01-20
- CAS:2162982-11-6
- Min. Order:
- Purity: 99.85%
- Supply Ability: 10g
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| | BAY-218 Basic information |
| Product Name: | BAY-218 | | Synonyms: | BAY2335218;BAY-2335218;BAY 2335218;BAY218;BAY 218;BAY-218;BAY-218;CPD3504;BAY-2335218;AHR antagonist 1;4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2-(3-fluorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-3-oxo-;6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide;(S)-6-(4-Chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2，3-dihydropyridazine-4-carboxamide | | CAS: | 2162982-11-6 | | MF: | C20H17ClFN3O3 | | MW: | 401.82 | | EINECS: | | | Product Categories: | | | Mol File: | 2162982-11-6.mol |  |
| | BAY-218 Chemical Properties |
| density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:80.0(Max Conc. mg/mL);199.09(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);49.77(Max Conc. mM) | | form | Solid | | pka | 11.81±0.20(Predicted) | | color | Light yellow to yellow |
| | BAY-218 Usage And Synthesis |
| Uses | BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses[1]. | | in vivo | BAY-218 (example 23) (p.o; 30 mg/kg; bid) has good anti-tumor effect combinated with aPD-L1[1]. | Animal Model: | Balb/c mice (subcutaneously CT26 cells)[1] | | Dosage: | 30 mg/kg | | Administration: | p.o, bid | | Result: | Significantly decreased tumors size combinated with aPD-L1. |
| | References | [1] Norbert Schmees, et al. 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides. WO2017202816A1. |
| | BAY-218 Preparation Products And Raw materials |
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