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| | IGF-I (24-41) Basic information |
| Product Name: | IGF-I (24-41) | | Synonyms: | INSULIN-LIKE GROWTH FACTOR I FRAGMENT 24-41, HUMAN;INSULIN-LIKE GROWTH FACTOR I (24-41);IGF-I FRAG 24-41 HUMAN;IGF-I (24-41);H-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-;H-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-OH;H2N-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-OH;TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR | | CAS: | 135861-49-3 | | MF: | C88H133N27O28 | | MW: | 2017.16 | | EINECS: | | | Product Categories: | | | Mol File: | 135861-49-3.mol |  |
| | IGF-I (24-41) Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | form | Solid | | color | White to off-white | | Sequence | Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr |
| | IGF-I (24-41) Usage And Synthesis |
| Uses | IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development[1][2][3]. | | in vivo | IGF-I (24-41) (ICV; 200 ng dose; 2 μL; postnatal days 2, 4, and 7) regulates somatic growth and behavioral development[2].
| Animal Model: | Mice of an outbred Swiss-derived strain (CD-l) weighing 30-33g (virgin males) or 28-30g (nulliparous females)[2] | | Dosage: | 200 ng dose; 2 μL | | Administration: | ICV; postnatal days (PND) 2, 4, and 7 | | Result: | Increased the rate of ultrasonic calls of the pups measured on PND8.
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| | References | [1] Puche JE, et al. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012 Nov 14;10:224. DOI:10.1186/1479-5876-10-224
[2] D Santucci, et al. IGF-I and IGF-I24-41 but not IGF-I57-70 affect somatic and neurobehavioral development of newborn male mice. Brain Res Bull. 1994;35(4):367-71. DOI:10.1016/0361-9230(94)90115-5
[3] Dan Meng, et al. Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radic Biol Med. 2007 Jun 1;42(11):1651-60. DOI:10.1016/j.freeradbiomed.2007.01.037 |
| | IGF-I (24-41) Preparation Products And Raw materials |
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