LY 303511

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CAS:154447-38-8
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  • LY 303511
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  • $562.00 / 50mg
  • 2026-05-11
  • CAS:154447-38-8
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  • Purity: 99.91%
  • Supply Ability: 10g
  • LY 303511
  • LY 303511 pictures
  • $2.00 / 100kg
  • 2026-04-17
  • CAS:154447-38-8
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
  • LY 303511
  • LY 303511 pictures
  • $1.00 / 1KG
  • 2019-12-20
  • CAS:154447-38-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100kgs
LY 303511 Basic information
Product Name:LY 303511
Synonyms:LY 303511; LY303511;2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one;8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one;8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one LY303511;LY303511, >=98%;4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-;LY-303511(Nv-128);8-phenyl-2-(piperazin-1-yl)-4H-chromen-4-one
CAS:154447-38-8
MF:C19H18N2O2
MW:306.36
EINECS:
Product Categories:Inhibitors
Mol File:154447-38-8.mol
LY 303511 Structure
LY 303511 Chemical Properties
Boiling point 496.1±45.0 °C(Predicted)
density 1.237±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
pka9.20±0.10(Predicted)
form Amber solid
color amber
InChI1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2
InChIKeyNGAGMBNBKCDCDJ-UHFFFAOYSA-N
Safety Information
WGK Germany WGK 1
Storage Class11 - Combustible Solids
MSDS Information
LY 303511 Usage And Synthesis
UsesLY 303511 is an inactive analog of the phosphoinositide 3-kinase inhibitor LY294002.
DefinitionChEBI: 8-phenyl-2-(1-piperazinyl)-1-benzopyran-4-one is a N-arylpiperazine.
Biological ActivityNegative control compound with respect to LY 294004 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-onehydrochloride ) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (K v ) channels (IC 50 = 64.6 μ M) and inhibits IL-1 β -stimulated NF- κ B activation, attenuating MCP-1 expression. Anti-proliferative.
in vivo

Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm3, at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo[4].

LY 303511 Preparation Products And Raw materials
Tag:LY 303511(154447-38-8) Related Product Information
Isopropylamine 2,5-Dimethoxyaniline tert-Butyl 1-piperazinecarboxylate 2-(Etilmetilammino)-8-fenilcromone [Italian] 2-(Diethylamino)-8-phenyl-4H-1-benzopyran-4-one TRANS-3-(DIETHYLAMINO)-1-(2-HYDROXY- LY 303511 4H-1-Benzopyran-4-one, 2-(diethylamino)- 2-(Dimethylamino)-8-phenyl-4H-1-benzopyran-4-one