S29434 manufacturers
- S29434
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- $688.00
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2026-07-27
- CAS:874484-20-5
- Purity: 99.41%
- Supply Ability: 10g
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| Product Name: | S29434 | | Synonyms: | S29434;2-Furancarboxamide, N-[2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl]-;N-(2-(2-Methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide;cell-permeable,inhibit,selective,S 29434,HepG2,mice,NMDPEF,S-29434,ROS,Autophagy,S29434,Inhibitor,memory;N-(2-{5-methoxy-1,6,11-triazatetracyclo[7.7.0.02,?.01?,1?]hexadeca-2(7),3,5,8,10(15),11,13-heptaen-8-yl}ethyl)furan-2-carboxamide;S29434, 10 mM in DMSO | | CAS: | 874484-20-5 | | MF: | C21H18N4O3 | | MW: | 374.39 | | EINECS: | | | Product Categories: | | | Mol File: | 874484-20-5.mol |  |
| | S29434 Chemical Properties |
| Boiling point | 695.0±55.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 19.29 mg/mL (51.52 mM); Water: < 0.1 mg/mL (insoluble) | | pka | 13.92±0.46(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | S29434 Usage And Synthesis |
| Uses | S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1]. | | in vivo | S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo[1]. | Animal Model: | CH3 wild-type mice[1] | | Dosage: | 1 and 15 mg/kg | | Administration: | Intraperitoneal injection; 1 and 15 mg/kg once | | Result: | Positively affected memory by inhibiting QR2. |
| | References | [1] Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285. DOI:10.1124/mol.118.114231 |
| | S29434 Preparation Products And Raw materials |
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