S29434

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Products Intro: Product Name:S29434
CAS:874484-20-5
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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CAS:874484-20-5
Purity:99.92% Package:50mg;589USD|5mg;122USD|1mg;51USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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CAS:874484-20-5
Purity:99% Package:5KG;1KG Remarks:S29434
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CAS:874484-20-5
Purity:98% Package:5mg Remarks:V28990
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Products Intro: Product Name:S29434
CAS:874484-20-5
Package:1 mg;1 mL * 10mM (in DMSO);10 mg;100 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

S29434 manufacturers

  • S29434
  • S29434 pictures
  • $51.00 / 1mg
  • 2025-04-27
  • CAS:874484-20-5
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  • Purity: 99.92%
  • Supply Ability: 10g
S29434 Basic information
Product Name:S29434
Synonyms:S29434;2-Furancarboxamide, N-[2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl]-;N-(2-(2-Methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide;cell-permeable,inhibit,selective,S 29434,HepG2,mice,NMDPEF,S-29434,ROS,Autophagy,S29434,Inhibitor,memory;N-(2-{5-methoxy-1,6,11-triazatetracyclo[7.7.0.02,?.01?,1?]hexadeca-2(7),3,5,8,10(15),11,13-heptaen-8-yl}ethyl)furan-2-carboxamide;S29434, 10 mM in DMSO
CAS:874484-20-5
MF:C21H18N4O3
MW:374.39
EINECS:
Product Categories:
Mol File:874484-20-5.mol
S29434 Structure
S29434 Chemical Properties
Boiling point 695.0±55.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 19.29 mg/mL (51.52 mM); Water: < 0.1 mg/mL (insoluble)
form Solid
pka13.92±0.46(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
S29434 Usage And Synthesis
UsesS29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1].
in vivo

S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo[1].

Animal Model:CH3 wild-type mice[1]
Dosage:1 and 15 mg/kg
Administration:Intraperitoneal injection; 1 and 15 mg/kg once
Result:Positively affected memory by inhibiting QR2.
References[1] Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285. DOI:10.1124/mol.118.114231
S29434 Preparation Products And Raw materials
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