Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy-

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Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Basic information
Product Name:Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy-
Synonyms:Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy-;Lipid Uptake Inhibitor, ML278
CAS:1604821-43-3
MF:C23H23N3O5S
MW:453.51
EINECS:
Product Categories:
Mol File:1604821-43-3.mol
Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Structure
Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Chemical Properties
density 1.339±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 5mg/mL
pka6.84±0.50(Predicted)
form solid
color light yellow
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Usage And Synthesis
UsesA cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC50 = 6 nM). Shown to block the uptake of [3H] labeled cholesteryl oleate ester ([3H]CE) from [3H]CE-HDL (IC50 = 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 µM). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Biological ActivityCell permeable: yes', 'Primary Target
scavenger receptor class B type I', 'Reversible: yes
Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy- Preparation Products And Raw materials
Tag:Benzamide, N-[4-[2,3-dihydro-1-(2-methoxyacetyl)-1H-indol-5-yl]-2-thiazolyl]-3,5-dimethoxy-(1604821-43-3) Related Product Information
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