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| | 1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC Basic information |
| Product Name: | 1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC | | Synonyms: | 1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC;4,7R-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacosan-11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19,20,20,21,21,22,22,23,23,24,24,25,25,26,26,27,27,27-d35-1-aminium-10-14C, 4-oxide, inner salt;18:0-d35/0:0 PC | | CAS: | 327178-92-7 | | MF: | C26H54NO7P | | MW: | 523.69 | | EINECS: | | | Product Categories: | | | Mol File: | 327178-92-7.mol |  |
| | 1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Chloroform:Methanol (1:1): soluble,Ethanol: 2 mg/ml | | form | A solid |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC Usage And Synthesis |
| Uses | 1-Stearoyl-sn-glycero-3-phosphocholine-d35 is deuterium labeled 1-Stearoyl-sn-glycero-3-phosphocholine (HY-125771). 1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells[1]. | | Biological Activity | 1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-stearoyl-2-hydroxy-sn-glycero-3-PC by GC- or LC-MS. 1-Stearoyl-2-hydroxy-sn-glycero-3-PC is a saturated lysophosphatidylcholine. It increases IL-1β production in isolated human blood monocytes when used at a concentration of 12.5 μM.1 Plasma levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PC are decreased in patients with lung cancer.2 | | IC 50 | HDAC3; p-STAT3 | | References | 1.Liu-Wu, Y., Hurt-Camejo, E., and Wiklund, O.Lysophosphatidylcholine induces the production of IL-1β by human monocytesAtherosclerosis137(2)351-357(1998)
2.Dong, J., Xiaoming, C., Zhao, L., et al.Lysophosphatidylcholine profiling of plasma: Discrimination of isomers and discovery of lung cancer biomarkersMetabolomics6(4)478-488(2010) |
| | 1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC Preparation Products And Raw materials |
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