| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:RIP1 kinase inhibitor 1
CAS:2095515-38-9
Package:1removed
|
RIP1 kinase inhibitor 1 manufacturers
|
| | RIP1 kinase inhibitor 1 Basic information |
| Product Name: | RIP1 kinase inhibitor 1 | | Synonyms: | RIP1 kinase inhibitor 1;1,5-Benzoxazepine-8-carbonitrile, 3-[3-chloro-2,4,5,7-tetrahydro-7-oxo-2-(phenylmethyl)-6H-pyrazolo[3,4-c]pyridin-6-yl]-2,3,4,5-tetrahydro-5-methyl-4-oxo-, (3S)-;RIP-1 kinase inhibitor 1,RIP1 kinase inhibitor 1 | | CAS: | 2095515-38-9 | | MF: | C24H20ClN5O3 | | MW: | 461.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2095515-38-9.mol |  |
| | RIP1 kinase inhibitor 1 Chemical Properties |
| Boiling point | 798.9±60.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | solubility | Soluble in DMSO | | pka | -0.75±0.20(Predicted) | | form | Solid | | color | White to yellow |
| | RIP1 kinase inhibitor 1 Usage And Synthesis |
| Uses | RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1]. | | References | [1] Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, OrallyAvailable, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409. DOI:10.1021/acs.jmedchem.7b01647 |
| | RIP1 kinase inhibitor 1 Preparation Products And Raw materials |
|