(1α,1'S,4β)-Lanabecestat manufacturers
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| | (1α,1'S,4β)-Lanabecestat Basic information |
| Product Name: | (1α,1'S,4β)-Lanabecestat | | Synonyms: | (1α,1'S,4β)-Lanabecestat;(1α,1'S,4β)-AZD3293;(1α;4β)-AZD3293;4β)-Lanabecestat;(1α,1'S,4β) Lanabecestat,(1α,1'S,4β)Lanabecestat;Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]imidazol]-4''-amine, 4-methoxy-5''-methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'S,4β)-;(1Alpha,1'S,4Beta)-Lanabecestat | | CAS: | 1384082-96-5 | | MF: | C26H28N4O | | MW: | 412.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1384082-96-5.mol |  |
| | (1α,1'S,4β)-Lanabecestat Chemical Properties |
| Boiling point | 621.9±65.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (606.02 mM) | | pka | 4.60±0.60(Predicted) | | form | Solid | | color | Light yellow to khaki |
| | (1α,1'S,4β)-Lanabecestat Usage And Synthesis |
| Description | (1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is a Beta site APP Cleaving Enzymel (BACE1) inhibitor extracted from patent WO2012087237A1, compound 20a, has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively[1]. | | Uses | (1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM[1]. | | IC 50 | BACE1 | | References | [1]. Gabor Csjernyik, et al. Compounds and their use as bace inhibitors. WO2012087237A1. |
| | (1α,1'S,4β)-Lanabecestat Preparation Products And Raw materials |
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