6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride

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6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Basic information
Product Name:6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride
Synonyms:6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride;C1s-IN-1 (trihydrochloride)
CAS:1376162-36-5
MF:C16H20ClN5
MW:317.82
EINECS:
Product Categories:
Mol File:1376162-36-5.mol
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Structure
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Chemical Properties
form Solid
color White to light yellow
Safety Information
MSDS Information
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Usage And Synthesis
UsesC1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1].
References[1] Xu X, et al., Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212(4):689-701. DOI:10.4049/jimmunol.2300630
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride Preparation Products And Raw materials
Tag:6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride(1376162-36-5) Related Product Information
3-Pyridinecarboximidamide, 6-(4-phenyl-1-piperazinyl)- 3-Pyridinemethanamine, 6-(4-phenyl-1-piperazinyl)- 6-(4-Phenylpiperazin-1-yl)pyridine-3-carbonitrile 3-Pyridinemethanamine, 2-(4-phenyl-1-piperazinyl)- 6-[4-(3-methylphenyl)piperazin-1-yl]pyridine-3-carbonitrile AKOS B034222