SB 221284

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SB 221284 manufacturers

  • SB-221284
  • SB-221284 pictures
  • $1520.00
  • 2026-04-21
  • CAS:196965-14-7
  • Purity:
  • Supply Ability: 10g
SB 221284 Basic information
Product Name:SB 221284
Synonyms:5-(METHYLTHIO)-1-(3-PYRIDYLCARBAMOYL)-6-(TRIFLUOROMETHYL)INDOLINE;2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE;SB 221284;1H-Indole-1-carboxamide, 2,3-dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-
CAS:196965-14-7
MF:C16H14F3N3OS
MW:353.36
EINECS:
Product Categories:
Mol File:196965-14-7.mol
SB 221284 Structure
SB 221284 Chemical Properties
Melting point 262-264 °C
Boiling point 536.2±50.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: ~14 mg/mL, soluble
pka13.13±0.20(Predicted)
form solid
color white
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
SB 221284 Usage And Synthesis
UsesSB 221284 is a potent, selective SR-2C/SR-2B antagonist.
DefinitionChEBI: SB 221284 is an indolyl carboxylic acid.
Biological ActivityPotent, selective 5-HT 2C/2B receptor antagonist. pK i values are 6.4, 7.9 and 8.6 for 5-HT 2A , 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo .
in vivo

SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]

Animal Model:Male Sprague Dawley rats (250–360 g)[1]
Dosage:0.1~1 mg/kg
Administration:I.p.
Result:Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model:Male Sprague Dawley rats (250–360 g)[1]
Dosage:1 mg/kg
Administration:I.p.
Result:Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
IC 505-HT2A Receptor: 6.4 (pKi); 5-HT2B Receptor: 7.9 (pKi); 5-HT2C Receptor: 8.6 (pKi)
SB 221284 Preparation Products And Raw materials
Tag:SB 221284(196965-14-7) Related Product Information
4-Methylthio-3-(trifluoromethyl)aniline 2-(Trifluoromethyl)thiophenol 6-Methyl-2,3-dihydro-1H-indole 2-(4-Trifluoromethyl-phenyl)-ethylamine 6-(Trifluoromethyl)indoline SB 221284