| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
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| | L-655,240 Basic information |
| Product Name: | L-655,240 | | Synonyms: | L-655,240;1-((4-Chlorophenyl)methyl)-5-fluoro-alpha,alpha-3-trimethyl-(1H)-indole-2-propanoicacid;1-(4-Chlorobenzyl)-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid;1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid;3-[1-(4-CHLOROBENZYL)-5-FLUORO-3-METHYL-INDOL-2-YL]-2,2-DIMETHYL PROPANOIC ACID;1-[(4-CHLOROPHENYL)METHYL]-5-FLUORO-A,A,3-TRIMETHYL-1H-INDOLE-2-PROPANOIC ACID;JLPYLHLUHJOPNL-UHFFFAOYSA-N;1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl- | | CAS: | 103253-15-2 | | MF: | C21H21ClFNO2 | | MW: | 373.85 | | EINECS: | | | Product Categories: | Prostanoid receptor and related | | Mol File: | 103253-15-2.mol |  |
| | L-655,240 Chemical Properties |
| Boiling point | 548.7±50.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: 30 mg/mL | | form | solid | | pka | 4.82±0.10(Predicted) | | color | off-white |
| | L-655,240 Usage And Synthesis |
| Uses | L-655,240 is a selective and potent thromboxane and prostaglandin endoperoxide antagonist. Also used in the structure-based and ligand-based drug design for microsomal prostaglandins E synthase-1 inhibitors. | | Definition | ChEBI: 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methyl-2-indolyl]-2,2-dimethylpropanoic acid is a methylindole. | | Biological Activity | Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist. pA 2 values are 8-8.4 in guinea pig smooth muscle; IC 50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo . | | in vivo | L 655240 (0.3 mg/kg; i.v.; single dose) changes heat rate, arterial and pulmonary arterial blood pressure, and cardiac output in canine model[1].
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| | L-655,240 Preparation Products And Raw materials |
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